The links from John Hopkins, the CDC and Harvard all focus on vaping, and so are irrelevant to the question of nicotine rather than the delivery methods.
The first link has nothing wrong in it. It’s correct nicotine is toxic. So is caffeine - the LD50 of caffeine in humans is reasonably high, many grams. To the issue of ingestion, the issue is toxicity at doses people are likely to deal with.
To the cancer links, again without looking at delivery methods, this is meaningless. To let me quote one small part:
Thus, the induced activation of nAChRs in lung and other tissues by nicotine can promote carcinogenesis by causing DNA mutations[26] Through its tumor promoter effects, it acts synergistically with other carcinogens from automobile exhausts or wood burning and potentially shorten the induction period of cancers[43] [Table 2].
This makes sense. Don’t inhale lots of particulates combined with nicotine in other words.
There are also many other parts of the article that are useful. E.g. it’s perfectly reasonable to accept that e.g. if you are on chemo you should stay off nicotine, and if you breastfeed you should stay off nicotine.
What the article does not show is that nicotine, as opposed to delivery methods like inhalation, is much worse than other drugs we’re perfectly fine with.
I’ll note that the article also includes things in its conclusion that it has categorically not cites studies in support of. E.g. it just assumes the addiction potential is proven (it is, but putting that in the conclusion of a paper without citing sources is really poor form, especially in a paper claiming to set out the issues with nicotine in isolation rather than smoking).
It also tried to drive up the scare factor by pointing out its toxicity at doses irrelevant for human consumption (e.g. as an insecticide; if wildly irrelevant doses should be considered, then we could write the same paper about how apples should be banned because they contain cyanide).
The “Materials and methods” section also goes on to say “Studies that evaluated tobacco use and smoking were excluded” but then goes on to make multiple arguments on the basis of harm caused by smoking (e.g. “Nicotine plays a role in the development of emphysema in smokers, by decreasing elastin in the lung parenchyma and increasing the alveolar volume”) and cites a paper focused on smoking, in direct contradiction of the claim they made (“Endoh K, Leung FW. Effects of smoking and nicotine on the gastric mucosa: A review of clinical and experimental evidence. Gastroenterology. 1994;107:864–78.”)
So, yes, if you make claims about how you’re going to address nicotine rather than smoking, and then go on to address smoking and other means of inhalation intermingled with the rest, and if you leap to conclusions you’ve not cited works in support of, and if you throw out risks without linking them causally to nicotine, you can make nicotine look very bad.
They also end with subjective statements they’ve not even attempted to support properly. E.g. they’ve gone from “here is why it’s dangerous” to “it should be restricted”, but if that was valid logic, we should restrict sales of apples too, most cleaning agents, all caffeinated products, housepaint, paint thinners, and a host of other things, it’s a specious argument and fitting that such a badly argued paper ends with it. That this passed peer review is an incredible indictment of the journal which published it.
That doesn’t mean nicotine is risk-free, but compared to other things we’re happy to ingest, I stand by my statement. But don’t inhale it.
“I haven’t read this, but let me misrepresent what the thing I didn’t read says”.
I have not argued it isn’t unhealthy. I have argued it’s one of the safer stimulants we have, unless you ingest it in a way that is dangerous (e.g. inhalation). That does not mean it’s free of downsides, but neither are a whole lot of things we still decide it’s fine to use.
Next time maybe try abstaining from replying to something you’ve not bothered to read.
You just confirmed what I said. “One of the safest”
And yeah you wrote way more shit than you should ever expect people to read. Maybe abstain from writing 10,000 words ever but especially if you’re wrong
No, you made the false claim that I said it isn’t unhealthy. “One of the safest” is not the same as “isn’t unhealthy”.
If you can’t be bothered to read my ~600 words in reply to someone else and not directed at you, that is entirely your choice. Nobody is forcing you to. Neither are anyone forcing you to blatantly misrepresent what I’ve claimed, however.
Your hyperbole was so idiotic that I took 10 seconds to pipe the contents to “wc” to highlight just how lazy you were before you misrepresented what you reply to, yes. That it was such a chore for you to read 600 words before making up a strawman to reply to does indeed say more than you did with words.
The links from John Hopkins, the CDC and Harvard all focus on vaping, and so are irrelevant to the question of nicotine rather than the delivery methods.
The first link has nothing wrong in it. It’s correct nicotine is toxic. So is caffeine - the LD50 of caffeine in humans is reasonably high, many grams. To the issue of ingestion, the issue is toxicity at doses people are likely to deal with.
To the cancer links, again without looking at delivery methods, this is meaningless. To let me quote one small part:
This makes sense. Don’t inhale lots of particulates combined with nicotine in other words. There are also many other parts of the article that are useful. E.g. it’s perfectly reasonable to accept that e.g. if you are on chemo you should stay off nicotine, and if you breastfeed you should stay off nicotine.
What the article does not show is that nicotine, as opposed to delivery methods like inhalation, is much worse than other drugs we’re perfectly fine with.
I’ll note that the article also includes things in its conclusion that it has categorically not cites studies in support of. E.g. it just assumes the addiction potential is proven (it is, but putting that in the conclusion of a paper without citing sources is really poor form, especially in a paper claiming to set out the issues with nicotine in isolation rather than smoking).
It also tried to drive up the scare factor by pointing out its toxicity at doses irrelevant for human consumption (e.g. as an insecticide; if wildly irrelevant doses should be considered, then we could write the same paper about how apples should be banned because they contain cyanide).
The “Materials and methods” section also goes on to say “Studies that evaluated tobacco use and smoking were excluded” but then goes on to make multiple arguments on the basis of harm caused by smoking (e.g. “Nicotine plays a role in the development of emphysema in smokers, by decreasing elastin in the lung parenchyma and increasing the alveolar volume”) and cites a paper focused on smoking, in direct contradiction of the claim they made (“Endoh K, Leung FW. Effects of smoking and nicotine on the gastric mucosa: A review of clinical and experimental evidence. Gastroenterology. 1994;107:864–78.”)
So, yes, if you make claims about how you’re going to address nicotine rather than smoking, and then go on to address smoking and other means of inhalation intermingled with the rest, and if you leap to conclusions you’ve not cited works in support of, and if you throw out risks without linking them causally to nicotine, you can make nicotine look very bad.
They also end with subjective statements they’ve not even attempted to support properly. E.g. they’ve gone from “here is why it’s dangerous” to “it should be restricted”, but if that was valid logic, we should restrict sales of apples too, most cleaning agents, all caffeinated products, housepaint, paint thinners, and a host of other things, it’s a specious argument and fitting that such a badly argued paper ends with it. That this passed peer review is an incredible indictment of the journal which published it.
That doesn’t mean nicotine is risk-free, but compared to other things we’re happy to ingest, I stand by my statement. But don’t inhale it.
I didn’t read this novel but you’re arguing nicotine isn’t unhealthy and that makes you wrong
“I haven’t read this, but let me misrepresent what the thing I didn’t read says”.
I have not argued it isn’t unhealthy. I have argued it’s one of the safer stimulants we have, unless you ingest it in a way that is dangerous (e.g. inhalation). That does not mean it’s free of downsides, but neither are a whole lot of things we still decide it’s fine to use.
Next time maybe try abstaining from replying to something you’ve not bothered to read.
You just confirmed what I said. “One of the safest”
And yeah you wrote way more shit than you should ever expect people to read. Maybe abstain from writing 10,000 words ever but especially if you’re wrong
No, you made the false claim that I said it isn’t unhealthy. “One of the safest” is not the same as “isn’t unhealthy”.
If you can’t be bothered to read my ~600 words in reply to someone else and not directed at you, that is entirely your choice. Nobody is forcing you to. Neither are anyone forcing you to blatantly misrepresent what I’ve claimed, however.
You went and counted the words. That says more than I could
Your hyperbole was so idiotic that I took 10 seconds to pipe the contents to “wc” to highlight just how lazy you were before you misrepresented what you reply to, yes. That it was such a chore for you to read 600 words before making up a strawman to reply to does indeed say more than you did with words.
Get laid