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Cake day: June 21st, 2023

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  • In a recent study published in the journal Nature Human Behaviour, researchers used a large, binational cohort (total n = 4,731,778) to investigate the short- and long-term associations between SARS-CoV-2 infections and subsequent adverse neuropsychiatric outcomes. They used exposure-driven propensity score matching to compare their samples’ outcomes against the general population and individuals with a non-SARS-CoV-2 respiratory infection.

    Study findings revealed that COVID-19 survivors were at significantly heightened risk of developing cognitive deficits, insomnia, encephalitis, and at least four other neuropsychiatric sequelae. Specific conditions included Guillain-Barré syndrome (aHR, 4.63), cognitive deficit (aHR, 2.67), insomnia (aHR, 2.40), anxiety disorder (aHR, 2.23), encephalitis (aHR, 2.15), ischaemic stroke (aHR, 2.00), mood disorder (aHR, 1.93), and nerve/nerve root/plexus disorder (aHR, 1.47). Encouragingly, vaccination was observed to attenuate the neuropsychiatric effects of the infection