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I have never seen Discovery and SNW is very enjoyable. I am sure I am missing context, but I don’t think it is significant enough to make Discovery mandatory.
I have never seen Discovery and SNW is very enjoyable. I am sure I am missing context, but I don’t think it is significant enough to make Discovery mandatory.
hear ye
Yeah, it’d be a real issue.
I played Like a Dragon with no background and it was a great experience. Really wacky in a satisfying way. Only grievance is there is ~10 hours of cut scenes to beat the game.
I commented this elsewhere, but to answer your question,
Zolgemsma is a modified version of adeno associated virus and has to be grown under specific conditions. It costs $500k-$1m per production. It’s also a one time injection that functionally cures the person of the disease. There are a couple other options but for comparison, the other therapeutic is Spinraza which is an intermittent intrathecal infusion which is $805,000 for the first year of therapy and $380,000 per year thereafter for the rest of your life.
SMA type I also is 100% fatal by year 2-3 and the baby dies without being able to even lift their head. It’s a terrible prognosis.
To be clear, I think we should bear the actual costs of research, development, and manufacture as a society and not profiteer off the sick, but there are some contributory reasons for the price.
Zolgemsma is a modified version of adeno associated virus and has to be grown under specific conditions. It costs $500k-$1m per production.. It’s also a one time injection that functionally cures the person of the disease. There are a couple other options but for comparison, the other therapeutic is Spinraza which is an intermittent intrathecal infusion which is $805,000 for the first year of therapy and $380,000 per year thereafter for the rest of your life.
To be clear, I think we should bear the actual costs of research, development, and manufacture as a society and not profiteer off the sick, but there are some contributory reasons for the price.
Zolgemsma is a modified version of adeno associated virus and has to be grown under specific conditions. It costs $500k-$1m per production.
No one has given you an actual reply just assuming that the manufacturing costs for the drug are low. Zolgemsma is a modified version of adeno associated virus and has to be grown under specific conditions. It costs $500k-$1m per production.
Yeah there’s a logical inconsistency for sure, but I see the practical necessity of it.
It sounds odd but there was a Supreme Court about it. Essentially someone claimed they shouldn’t have to pay taxes on the profits of crime and the Court ruled they did. So they had to create a way for people to do that. For what it is worth, the 5th amendment protects you from incriminating yourself, so you are allowed to decline to provide the details of where the money came from, but it’s a bit like paying your parents for something you broke and then just not telling them what it is, and then expecting them not to look around the house.
“it would be an extreme if not an extravagant application of the Fifth Amendment to say that it authorized a man to refuse to state the amount of his income because it had been made in crime. … He could not draw a conjurer’s circle around the whole matter by his own declaration that to write any word upon the government blank would bring him into danger of the law.” … "It is urged, that, if a return were made, the defendant [Sullivan] would be entitled to deduct illegal expenses, such as bribery. This by no means follows, but it will be time enough to consider the question when a taxpayer has the temerity to raise it.”
Nethack is like the Jumanji of games. You finish it by introducing someone else to it.
Yeah, I didn’t say any of that but ok. HIPAA/employers actually require you to give law enforcement information in a variety of situations, including specifically the situation I mentioned:
To report PHI that the covered entity in good faith believes to be evidence of a crime that occurred on the covered entity’s premises (45 CFR 164.512(f)(5)).
HHS - When does the Privacy Rule allow covered entities to disclose information to law enforcement
I worked at a pharmacy and the only time it actually happened was when a patient tried to sell their Vicodin to an undercover cop outside the store. The cop came in and asked for the information about the prescription and we gave it to him.
The HIPAA Privacy Rule exception for law enforcement purposes, 45 CFR § 164.512(f), permits a covered entity (generally, healthcare providers, health plans and their business associates) to disclose PHI to law enforcement officials without patient authorization under certain circumstances.
Those pharmacies also have this exception listed in their Privacy Policy. I don’t like it either, but it is legal.
Allah loves wondrous variety!
The painted man! He haunts my dreams.
I once got Lufia II for SNES for $5 from Blockbuster. Absolutely amazing game and I still have it!
I recently found out about the Zelda: Link to the Past randomizer community. Essentially there is a method to modify the original game to randomize the item locations and other aspects of the game while ensuring the game can be completed. Each game has a seed so you can look it up if you get to stuck. I played through it once and it was a really interesting challenge since I didn’t get the bow until 60% of the way through the game.