My cat once brought in a North American shrew in the house and I thought “what a weird looking mouse!” So, I went to scoop it up in a dust pan and drop it out side and the little shit bit my finger! Anyways, got it outside and went to look it up and found out they (the NA shrew) were venomous! Luckily the bite was superficial and I only had slight redness for the night.

Fun fact about the shrew is apparently it is highly territorial and can defend a territory of > 1 square mile, and somehow my cat found the one shrew in a sq mile area in our backyard which is like a 1/16 acre neighborhood plot lol

Well, as a pharmacist whose been stable on 50mg of vyvanse for more than 3 years, your wife and Doc are both incorrect…

Both are stimulants, yes, but

Vyvanse is an amphetamine and works to produce more neurotransmitters you don’t already have.

Cocaine is a reuptake inhibitor… thus preventing the breakdown of neurotransmitters you do already have.

While fundamentally they may look like they’re doing the same thing, they are in fact 2 totally different mechanisms. Furthermore, in neurotransmitter depletion the effects of cocaine will severely diminish, where as amphetamines will thrive.

I believe Jesus also said

Matthew 7:5 Hypocrite! First remove the plank from your own eye, and then you will see clearly to remove the speck from your brother’s eye.

So maybe we should focus on our own paths in life rather than someone else’s life decision that has 0 bearing on whether you or I go to heaven or hell?

I mean why people are so obsessed with what people do in their own home, on their own dime, and their own time is beyond me.

Christofacists just want to control others. They don’t care what Jesus said. They don’t want to FOLLOW Jesus, They want to BE Jesus and tell others how to live.

Def not a math major (BS/PharmD), but your explanation was like seeing through a visual illusion for the first time! lol

I was always taught PEMDAS growing up, and that the MD and the AS was read left to right in an equation like above. But stating the division as a fraction completely changes my mind now about how this calculation works. I think what would happen in a calculation I use every day if the former was used.

Example: Cockcroft-Gault Equation (estimation of renal function)

(140-age)(kg) / 72(SCr) vs (140-age) X kg ➗72 X SCr

In the first eq (correct one) an 80yo patient who weighs 65kg and has an SCr ~ 1.5 = 36.11

In the latter it = 81.25 (waaay too high for an 80yo lol)

edit: calculation variable

Maybe it’s early in the morning and I am not quite awake, but I have no idea what you are talking about. Nor do I understand how forgetting to do something makes you able to do something, and somehow that relates to a hot stove?

Can you explain what the “hot stove” example is? Maybe that is what I’m missing.

Are you using the EA version or the standard?

So unless you live in an area with fiber, asymmetrical speeds are pretty typical… I’m not sure if it is because it’s all coax so there are infrastructure limitations? But it’s actually gotten faster because 6 months ago my upload was only 30 mbit/s.

Once fiber is in my area I’ll switch to that, but symmetrical will add more cost…but of course it will lol

According to the CDC:

more than 93.1% of abortions were performed at ≤13 weeks’ gestation; a smaller number of abortions (5.8%) were performed at 14–20 weeks’ gestation, and even fewer (0.9%) were performed at ≥21 weeks’ gestation.

1. So, 93.1% aren’t even fetuses yet, they are zygotes (which is a clump of cells)

2. the other 6.9% are fetuses not babies.

• A baby is a non-clinical term for an “infant” (def: a very young child under the age of 1 years old) that has bodily autonomy separate from the mother.

So, to recap, abortion is not killing a baby

pay $180/month for 1gbit down/100mbit up and it is unlimited… It would be $130 for 1.75TB, but I wanted unlimited and that is an extra $50/month

No, not aspirin. We know aspirin very well in the medical community.

TBF there are drugs out there that we do not know the MOA of, like methocarbamol (from the national institute of health: “The exact mechanism of action of methocarbamol remains unknown; similarly unknown is the relationship between musculoskeletal pain and muscle spasm” lol)

So for long term safety, it is based on animal and human studies. These studies happen for multiple years prior to being put on the market (for the most part, though that is a story for a different day). Then after the drug is on the market, the drug company is required to do “Postmarket Clinical Studies” to show that their drug is still doing what it was initial shown to do; furthermore, to look for safety events of said drug.

A really famous case of a bungled postmark study was Vioxx. Vioxx is/was a Cox-2 specific pain medication. In the initial and postmarket studies they found that it had an increased risk of heart attack (in some cases up to 88% increased risk). The company Merck held the information from the public and FDA. They were forced to take the drug off the market in 2004. Technically in short bursts Vioxx was probably safe, but long term it was not.

Well how specific is enough to say we do or don’t know how a drug works?

In particular we do know that ASA and other NSAIDS work by inhibiting the activity of the enzyme called cyclooxygenase which leads to the formation of prostaglandins that cause inflammation, swelling, pain and fever. It blocks both COX 1 and 2, though only COX 2 is responsible inflammation. Furthermore, The antithrombotic action of aspirin is due to inhibition of platelet function by acetylation of the platelet cyclooxygenase at the functionally important amino acid serine529.

Now contrast ASA with Acetaminophen …

We know that Acetaminophen also inhibits COX, but only in the CNS and not peripherally. Also, it is only thought that it potentially blocks pain signals via the serotonergic pain pathway.

I would say we know a hell of a lot about aspirin … Acetaminophen not so much on the MOA side of things, however it has been studied so much that we know the safety/toxicity profile like the back of our hands. Either way probably not the best 2 examples to use for your argument.

How do you tell you parents goodbye when the next massacre hits though?

Christian brings up some great points worthy of consideration; however, if your going to use traditional routing through their network (A/cname) your still doing the same thing. CF will still see your traffic.

The second thing I should say is, I only use zero trust for websites I share with family. So, I have a Searxng and wef/voyager dockers running through zero trust.

For admin, homeassistant/iot/ip cams, I use an always on IPSec vpn on my iPhone, iPad, and steam deck (take it to work and plug into 3rd monitor) … this is cool because I get 24/7 ad blocking no matter where I am because it routes all my traffic through my pihole at home. This is a great solution for a single person, but I do not want to manage vpn access for multiple ppl. So, I agree with christian in NOT putting admin stuff/sensitive info behind CF at all (zero trust OR tradition web routing) unless you fully trust them. Otherwise do a 24/7 vpn like I do.

I do this for some dockers in my unraid, except I use the zero trust tunnels. MUCH easier, can use SSL, and can set up a login page for users. Also, you don’t have to open any ports on your router!

Im not sure about synology, but I would assume you can find a “cloudflared” docker in the app store.

check out this youtube video for a good explanation: https://www.youtube.com/watch?v=ZvIdFs3M5ic

Well a very merry unbirthday to you as well!