I’m a big fan and longtime reader of Derek Lowe. He called attention to suppression of grant funding for hypotheses that challenged the amyloid hypothesis, and the shockingly partisan and dogmatic behavior of journal referees and NIH advisors in the field. I’ve been following his coverage ever since he started reporting disappointing readouts from clinical trials on the anti-amyloid mABs.
His concern that this class of therapy is “pathological science” (think cold fusion, or EmDrive, or string theory - not outright quackery, but hypotheses that are endlessly tweaked to justify the latest failures) are valid.
However, the newest mABs really do seem to have a small but statistically significant effect on slowing disease progression. Enough to justify the risks of brain swelling? Or the cost? Probably not. But I think Derek has perhaps swung too far in the opposite direction. It’s too early to call time on this therapeutic target. If it’s marginally but truly effective, we should try to figure out why, and keep tweaking the drugs to see if they can be improved.
Donepezil was a dead end, but it’s too early to say if Aduhelm is too.
I’m with the old man on this one. Antibodies can clear out amyloid and still it has no effect on progression of disease, amyloid secretion can be blocked upstream (like with small molecule protease inhibitors) and it still has no effect. Maybe this one hits something off-target, or maybe that effect is not even real, or maybe it’s some sort of statistical artifact. You’d stumble upon some false positive after trying so many times.
Aducanumab is dead in the water, trials shown no effect and it was abandoned by Biogen. This one is about lecanemab. Both have massive problems with brain edema and microhemorrages, which probably means these are not suitable for actual use. But don’t worry, they already have received their reward - FDA wanted to have something, anything to show up for Alzheimer and Biogen cashed in when stock price went up
think cold fusion, or EmDrive, or string theory
That’s a weird set - cold fusion or EmDrive can be tested and their physical principles are falsifiable - and they were - but string theory is different, because it’s not falsifiable.
If it’s marginally but truly effective,
That if makes some mighty heavy lifting here. I think that amyloid hypothesis is closer to cold fusion than to string theory in that it had already a couple of fatal experimental refutations thrown at it, but people still shove effort this way because there’s nothing else/copium/sunk cost combination
I’m a big fan and longtime reader of Derek Lowe. He called attention to suppression of grant funding for hypotheses that challenged the amyloid hypothesis, and the shockingly partisan and dogmatic behavior of journal referees and NIH advisors in the field. I’ve been following his coverage ever since he started reporting disappointing readouts from clinical trials on the anti-amyloid mABs.
His concern that this class of therapy is “pathological science” (think cold fusion, or EmDrive, or string theory - not outright quackery, but hypotheses that are endlessly tweaked to justify the latest failures) are valid.
However, the newest mABs really do seem to have a small but statistically significant effect on slowing disease progression. Enough to justify the risks of brain swelling? Or the cost? Probably not. But I think Derek has perhaps swung too far in the opposite direction. It’s too early to call time on this therapeutic target. If it’s marginally but truly effective, we should try to figure out why, and keep tweaking the drugs to see if they can be improved.
Donepezil was a dead end, but it’s too early to say if Aduhelm is too.
I’m with the old man on this one. Antibodies can clear out amyloid and still it has no effect on progression of disease, amyloid secretion can be blocked upstream (like with small molecule protease inhibitors) and it still has no effect. Maybe this one hits something off-target, or maybe that effect is not even real, or maybe it’s some sort of statistical artifact. You’d stumble upon some false positive after trying so many times.
Aducanumab is dead in the water, trials shown no effect and it was abandoned by Biogen. This one is about lecanemab. Both have massive problems with brain edema and microhemorrages, which probably means these are not suitable for actual use. But don’t worry, they already have received their reward - FDA wanted to have something, anything to show up for Alzheimer and Biogen cashed in when stock price went up
That’s a weird set - cold fusion or EmDrive can be tested and their physical principles are falsifiable - and they were - but string theory is different, because it’s not falsifiable.
That if makes some mighty heavy lifting here. I think that amyloid hypothesis is closer to cold fusion than to string theory in that it had already a couple of fatal experimental refutations thrown at it, but people still shove effort this way because there’s nothing else/copium/sunk cost combination